Лаборатория Нанобиотехнологий







1. Nanoparticle Beacons: Supersensitive Smart Materials with On/Off-Switchable Affinity to Biomedical Targets

V.R. Cherkasov, E.N. Mochalova, A.V. Babenyshev, A.V. Vasilyeva, P.I. Nikitin, M.P. Nikitin

ACS Nano 

DOI: 10.1021/acsnano.9b07569


2. Spindle-like MRI-active europium-doped iron oxide nanoparticles with shape-induced cytotoxicity from simple and facile ferrihydrite crystallization procedure

A.V. Lunin, I.L. Sokolov, I.V. Zelepukin, I.V. Zubarev, M.N. Yakovtseva, E. N. Mochalova, J.M. Rozenberg, M.P. Nikitin, E.L. Kolychev

RSC Adv.

DOI: 10.1039/C9RA10683A


3. Antibody-directed metal-organic framework nanoparticles for targeted drug delivery

V.R. Cherkasov, E.N. Mochalova, A.V. Babenyshev, J.M. Rozenberg, I.L. Sokolov, M.P. Nikitin

Acta Biomaterialia

DOI: 10.1016/j.actbio.2019.12.012


4. Precise quantitative analysis of cell targeting by particle-based agents using imaging flow cytometry and convolutional neural network

E.N. Mochalova, I.A. Kotov, J.M. Rozenberg, M.P. Nikitin

Cytom. Part A

DOI: 10.1002/cyto.a.23939


5. Development of magnetic particle-based theranostic agents with high specificity to cellular targets

E.N. Mochalova, M.N. Yakovtseva, S.P. Krechetov, V.R. Cherkasov, M.P. Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5


6. Smart Nanomaterials as Advanced Sensors and Targeted Drug Delivery Agents


Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5


7. MIL-100 coated nanoparticles as a potential tool for in vitro delivery of therapeutic agents

A. Ringaci, K.G. Shevchenko, V.R. Cherkasov, E.L. Kolychev

Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5


8. Development of the enzyme-responsive nanoparticle-based system for targeted drug delivery

K.G. Shevchenko, A.Ringaci, A.V. Babenyshev, M. P Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5





1. Analytical Platform with Selectable Assay Parameters Based on Three Functions of Magnetic Nanoparticles: Demonstration of Highly Sensitive Rapid Quantitation of Staphylococcal Enterotoxin B in Food

V.A. Bragina, S.L. Znoyko, A.V. Orlov, A.V. Pushkarev, M.P. Nikitin, P.I. Nikitin

Anal. Chem.

DOI: 10.1021/acs.analchem.9b01519


2. Rapid lateral flow assays based on the quantification of magnetic nanoparticle labels for multiplexed immunodetection of small molecules: application to the determination of drugs of abuse

N.V. Guteneva, S.L. Znoyko, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

Mikrochim. Acta

DOI: 10.1007/s00604-019-3726-9


3. Nanoparticle-based drug delivery via RBC-hitchhiking for the inhibition of lung metastases growth

I.V. Zelepukin, A.V. Yaremenko, V.O. Shipunova, A.V. Babenyshev, I.V. Balalaeva,
P.I. Nikitin, S.M. Deyev, M.P. Nikitin


DOI: 10.1039/c8nr07730d


4. Interferometric detection of chloramphenicol via its immunochemical recognition at polymer-coated nano-corrugated surfaces

A.E. Ivanov, A.V. Pushkarev, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

Sens. Actuators B: Chem.  

DOI: 10.1016/j.snb.2018.11.043


5. Synthesis of highly-specific stable nanocrystalline goethite-like hydrous ferric oxide nanoparticles for biomedical applications by simple precipitation method

A.V. Lunin, E.L. Kolychev, E.N. Mochalova, V.R. Cherkasov, M.P. Nikitin 

J. Colloid Interface Sci. 

DOI: 10.1016/j.jcis.2019.01.065


6. Magnetometry based method for investigation of nanoparticle clearance from circulation in a liver perfusion model 

I.V. Zelepukin, A.V. Yaremenko, E.V. Petersen, S.M. Deyev, V.R. Cherkasov, P.I. Nikitin, M.P. Nikitin


DOI: 10.1088/1361-6528/aafa3a


7. Self-assembling nanoparticles biofunctionalized with magnetite-binding protein for the targeted delivery to HER2/neu overexpressing cancer cells

V.O. Shipunova, P.A Kotelnikova, U.F Aghayeva, O.A Stremovskiy, I.A Novikov, A.A Schulga, M.P Nikitin, S.M Deyev

J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2018.09.015


8. Nano-biosensors based on dynamic light scattering

A.D. Levin, M.P. Nikitin, M.K. Alenichev, E.B. Drozhzhennikova, V.G. Grigorenko, A.S. Ringaci, I.P. Andreeva

Proc. SPIE 

DOI: 10.1117/12.2526055


9. Development of the SPR based method for real-time monitoring of surface cell markers density 

K.G. Shevchenko, A.V. Lunin, A.V. Popova, E.L. Kolychev, B.G. Gorshkov, M.P. Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-018-0128-4


10. Drug delivery with functionalized magnetic metal-organic framework nanoparticles 

A.V. Babenyshev, K.G. Shevchenko, A.V. Yaremenko, V.R. Cherkasov, P.I. Nikitin, M.P. Nikitin

Cell Death Dis.

DOI: 10.1038/s41420-018-0128-4


11. Fabrication of Highly Specific Drug Delivery Nanoagents and Investigation of Their Interaction with Cells

E. N. Mochalova, I.L. Sokolov, I.L. Nikitina, A.V. Orlov, K.G. Shevchenko

Cell Death Dis. 

DOI: 10.1038/s41420-018-0128-4





1. Advanced smart nanomaterials with integrated logic-gating and biocomputing: dawn of theranostic nanorobots 

A.A. Tregubov, P.I. Nikitin, M.P. Nikitin

Chem. Rev. 

DOI: 10.1021/acs.chemrev.8b00198 


2. Versatile platform for nanoparticle surface bioengineering based on SiO2-binding peptide and proteinaceous barnase*barstar interface

V.O. Shipunova, I.V. Zelepukin, O.A. Stremovskiy, M.P. Nikitin, A. Care, A. Sunna, A.V. Zvyagin, S.M. Deyev

ACS Appl. Mater. Interfaces. 

DOI: 10.1021/acsami.8b01627


3. Ultrasensitive detection enabled by nonlinear magnetization of nanomagnetic labels

M.P. Nikitin, A.V. Orlov, I.L. Sokolov, A.A. Minakov, P.I. Nikitin, J. Ding, S.D. Bader, E.A. Rozhkova, V. Novosad


DOI: 10.1039/c8nr01511b


4. Development and label-free investigation of logic-gating biolayers for smart biosensing

A.V. Orlov, A.V. Pushkarev, E.N. Mochalova, P.I. Nikitin, M.P. Nikitin

Sens. Actuators B: Chem. 

DOI: 10.1016/j.snb.2017.11.025


5. Ultrasensitive quantitative detection of small molecules with rapid lateral-flow assay based on high-affinity bifunctional ligand and magnetic nanolabels

S.L. Znoyko, A.V. Orlov, A.V. Pushkarev, E.N. Mochalova, N.V. Guteneva, A.V. Lunin, M.P. Nikitin, P.I. Nikitin

Anal. Chim. Acta 

DOI: 10.1016/j.aca.2018.07.012


6. Multiplex biosensing with highly sensitive magnetic nanoparticle quantification method

M.P. Nikitin, A.V. Orlov, S.L. Znoyko, V.A. Bragina, B.G. Gorshkov, T.I. Ksenevich, V.R. Cherkasov, P.I. Nikitin

J. Magn. Magn. Mater.

DOI: 10.1016/j.jmmm.2017.10.078


7. Magnetic hybrid magnetite/metal organic framework nanoparticles: facile preparation, post-synthetic biofunctionalization and tracking in vivo with magnetic methods

A.A. Tregubov, I.L. Sokolov, A.V. Babenyshev, P.I. Nikitin, V.R. Cherkasov, M.P. Nikitin

J. Magn. Magn. Mater.  

DOI: 10.1016/j.jmmm.2017.10.070


8. Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

K.G. Shevchenko, V.R. Cherkasov, I.L. Nikitina, A.V. Babenyshev, M.P. Nikitin

Appl. Nanosci. 

DOI: 10.1007/s13204-018-0659-2


9. Smart ligand-sensitive monolayers based on modified liposomes for biomedical applications

A.V. Lunin, V.R. Cherkasov, M.P. Nikitin 

J. Bioenerg. Biomembr.  


10. Paramagnetic colloidal ferrihydrite nanoparticles for MRI contrasting

I.L. Sokolov, V.R. Cherkasov, A.V. Vasilyeva, V.A. Bragina, M.P. Nikitin

Colloids Surf. A Physicochem. Eng. Asp.  

DOI: 10.1016/j.colsurfa.2017.11.062


11. Synthesis of Magnetic Nanoparticles Stabilized by Magnetite-Binding Protein for Targeted Delivery to Cancer Cells

P.A. Kotelnikova, V.O. Shipunova, U.F. Aghayeva, O.A. Stremovskiy, M.P. Nikitin, I.A. Novikov, A.A. Schulga, S.M. Deyev, R.V. Petrov

Dokl. Biochem. Biophys. 

DOI: 10.1134/S1607672918040051


12. Data on characterization of magnetic nanoparticles stabilized with fusion protein of Barstar and C-term part of Mms6

V.O. Shipunova, P.A. Kotelnikova, U.F. Aghayeva, O.A. Stremovskiy, A.A. Schulga, M.P. Nikitin, S.M. Deyev 

Data in Brief 

DOI: 10.1016/j.dib.2018.10.173


13. Data on characterization and validation of assays for ultrasensitive quantitative detection of small molecules: Determination of free thyroxine with magnetic and interferometric methods

A.V. Orlov, S.L. Znoyko, A.V. Pushkarev, E.N. Mochalova, N.V. Guteneva, A.V. Lunin, M.P. Nikitin, P.I.  Nikitin

Data in Brief 

DOI: 10.1016/j.dib.2018.10.145


14. Volumetric registration of magnetic nanoparticles for optimization of quantitative immunochromatographic assays for detection of small molecules

N.V. Guteneva, S.L. Znoyko, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

EPJ Web of Conferences 

DOI: 10.1051/epjconf/201818510006


15. Synthesis of Luminescent Magnetic Nanoparticles with Controllable Surface Properties 

I.V. Zelepukin,  V.O. Shipunova,  A.B. Mirkasymov,  P.I. Nikitin,  M.P. Nikitin,  S.M. Deyev

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435620


16. Intelligent Nanoparticle-Based Agents for Biomedical Applications: Rapid Design Using a Lateral Flow Assay

E.N. Mochalova, A.V. Pushkarev, P.I. Nikitin, M.P. Nikitin

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435254


17. Targeting of tumor tissues with magnetic nanoparticles 

M. Gonçalves,  R. Schwartz-Albiez,  P.I. Nikitin,  M.P. Nikitin,  F. Momburg

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435481


18. Smart Biolayers on Solid Phase: Rational Design and Investigation by Spectral-Phase Interferometry 

A.V. Pushkarev, E.N. Mochalova, S.L. Znoyko, M.P. Nikitin, A.V. Orlov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435399


19. Multifunctional Nanoagents for Logic-Gated Chemosensing, Diagnostics and Drug Delivery

M.P. Nikitin 

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435454


20. Modified Liposomes as Optical Probes, Magnetic Labels, and Drug Carriers

A.V. Lunin, A.V. Vasilyeva, B.G. Gorshkov, I.L. Sokolov, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435580


21. Nanocomplexes For in situ Detection of Small Molecules With Switchable Optical Properties

A.V. Babenyshev, K.G. Shevchenko, A.A. Tregubov, I.L. Nikitina, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435586


22. Development of SPR Based Tool For Monitoring of Self-Assembly of Heterogenous Nanoparticle Complexes

K.G. Shevchenko, A.V. Babenyshev, A.A. Tregubov, I.L. Nikitina, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435745


23. Fluorescent Superparamagnetic and Paramagnetic Agents for Bioimaging, Sensing and Cell Targeting

I.L. Sokolov, A.V. Vasilyeva, A.V. Lunin, A.V. Yaremenko, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435453


24. Multiplex Express In Vitro Diagnostics based on Magnetic Nanoparticles

V.A. Bragina, B.G. Gorshkov, N.V. Guteneva, M.P. Nikitin, P.I. Nikitin, A.V. Orlov, S.L. Znoyko

TechConnect Briefs 




1. Rapid dry-reagent immunomagnetic biosensing platform based on volumetric detection of nanoparticles on 3D structures

A.V. Orlov, V.A. Bragina, M.P. Nikitin, P.I. Nikitin

Biosens. Bioelectron. 

DOI: 10.1016/j.bios.2015.12.049


2. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interaction

V.O. Shipunova, M.P. Nikitin*, P.I. Nikitin, S.M. Deyev (* –corresponding author)


DOI: 10.1039/c6nr03507h


3. Multiplex Biosensing Based on Highly Sensitive Magnetic Nanolabel Quantification: Rapid Detection of Botulinum Neurotoxins A, B, and E in Liquids

A.V. Orlov, S.L. Znoyko, V.R. Cherkasov, M.P. Nikitin, P.I. Nikitin

Anal. Chem. 

DOI: 10.1021/acs.analchem.6b02066


4. Synthesis of magnetic silica nanomarkers with controlled physicochemical properties

I.V. Zelepukin, M.P. Nikitin, V.R. Cherkasov, P.I. Nikitin, S.M. Deyev, P.V. Petrov

Dokl. Biochem. Biophys. 

DOI: 10.1134/S1607672916050100


5. Mössbauer and X-ray study of biodegradation of (Fe3O4)-Fe-57 magnetic nanoparticles in rat brain

R.R. Gabbasov, V.M. Cherepanov, M.A. Chuev, A.A. Lomov, I.N. Mischenko, M.P. Nikitin, M.A. Polikarpov, V.Y. Panchenko

Hyperfine Interactions 

DOI: 10.1007/s10751-016-1237-1


6. Stimuli-responsive Nano- and Microstructures Based on Gold Nanoparticles

K.G. Shevchenko, V.R. Cherkasov, I.L. Sokolov, M.P. Nikitin

Proc. of the 2016 International conference laser optics (LO) 

DOI: 10.1109/LO.2016.7550012


7. Near infrared luminescent– magnetic nanoparticles for bimodal imaging in vivo 

I. V. Zelepukin, M P. Nikitin, A. V. Nechaev, A. V. Zvyagin, P. I. Nikitin, S. M. Deyev

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7550011


8. Lectin-based nanoagents for specific cell labelling and optical visualization

V.O. Shipunova, M.P. Nikitin, P.I. Nikitin, S.M. Deyev

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7550004


9. Nanorobots for Biomedical Applications

M.P. Nikitin

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7549994




1. Direct immunosensing by spectral correlation interferometry: assay characteristics versus antibody immobilization chemistry

A.G. Burenin, A.E. Urusov, A.V. Betin, A.V. Orlov, M.P. Nikitin, T.I. Ksenevich, , B.G. Gorshkov, A.V. Zherdev, B.B. Dzantiev, P.I. Nikitin

Anal. Bioanal. Chem. 

DOI: 10.1007/s00216-015-8600-y


2. Mössbauer study of exogenous iron redistribution between the brain and the liver after administration of 57Fe3O4 ferrofluid in the ventricle of the rat brain

D. Polikarpov, R. Gabbasov, V. Cherepanov, N. Loginova, E. Loseva, M. Nikitin, A. Yurenia, V. Panchenko

J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2014.10.084


3. A new real-time method for investigation of affinity properties and binding kinetics of magnetic nanoparticles

A.V. Orlov, M.P. Nikitin, V.A. Bragina, S.L. Znoyko, M.N. Zaikina, T.I. Ksenevich, B.G. Gorshkov, P.I. Nikitin

 J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2014.10.019


4. A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents

V.O. Shipunova, M.P. Nikitin, I.V. Zelepukin, P.I. Nikitin, S.M. Deyev, R.V. Petrov

Dokl. Biochem. Biophys.  

DOI: 10.1134/S1607672915050117


5. Complexes of magnetic nanoparticles and scFv antibodies for targeting and visualizing cancer cells

V.O. Shipunova, M.P. Nikitin, K.E. Mironova, S.M. Deyev, P.I. Nikitin

IEEE 15th International Conference on Nanotechnology (IEEE NANO) 

DOI: 10.1109/NANO.2015.7388956


6. Combined Photodynamic Thermochemotherapy of Glial Tumors Controlled by MRI and Electronic Sensor

N.A. Brusentsov, V.A. Polianskiy, A.V. Zhukov, M.V. Gulyaev, M.P. Nikitin, P.I. Nikitin, T.N. Brusentsova, V.D. Kuznetsov, O.A. Bocharova, A.Yu. Baryshnikov

Solid State Phenomena 

DOI: 10.4028/www.scientific.net/SSP.233-234.757





1. Biocomputing based on particle disassembly

M.P. Nikitin, V.O. Shipunova, S.M. Deyev, P.I. Nikitin