Laboratory of Nanobiotechnologies 




1. Imaging flow cytometry data analysis using convolutional neural network for quantitative investigation of phagocytosis

E.N Mochalova, I.A Kotov, D.A Lifanov, S. Chakraborti, M.P Nikitin

Biotechnology and Bioengineering

DOI: 10.1002/bit.27986


2. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo

V.O Shipunova, V.L Kovalenko, P.A Kotelnikova, A.S Sogomonyan, O.N. Shilova ,E.N  Komedchikova, A.V  Zvyagin, M.P. Nikitin, S. M. Deyev


DOI: 10.3390/pharmaceutics14010043





1. Label-free methods of multiparametric surface plasmon resonance and MPQ-cytometry for quantitative real-time measurements of targeted magnetic nanoparticles complexation with living cancer cells

V.O Shipunova, M.P Nikitin, M.M Belova, S.M Deyev

Materials Today Communications

DOI: 10.1016/j.mtcomm.2021.102978


2. Two-Step Targeted Drug Delivery Via Proteinaceous Barnase-Barstar Interface and PLGA-Based Nano-Carrier

V.O Shipunova, E.N Komedchikova, A.S Sogomonyan, P.A Kotelnikova, M.P Nikitin, S.M Deyev


DOI: 10.21203/


3. Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

A.A Sizikov, P.I Nikitin, M.P Nikitin


DOI: 10.3390/pharmaceutics13111927


4. Applications of Pristine and Functionalized Carbon Nanotubes, Graphene, and Graphene Nanoribbons in Biomedicine

M.G Burdanova, M.V Kharlamova, C. Kramberger, M.P Nikitin


DOI: 10.3390/nano11113020


5. Green Synthesis of Size-Controlled in Vivo Biocompatible Immunoglobulin-Based Nanoparticles by a Swift Thermal Formation

A.V Lunin, E.S Korenkov, E.N Mochalova, M.P Nikitin

ACS Sustainable Chemistry & Engineering

DOI: 10.1021/acssuschemeng.1c03409


6. Metal-organic frameworks for simultaneous gene and small molecule delivery in vitro and in vivo

A. Ringaci, A.V Yaremenko, K.G Shevchenko, S.D Zvereva, M.P Nikitin

Chemical Engineering Journal

DOI: 10.1016/j.cej.2021.129386


7. Long-term fate of magnetic particles in mice: A comprehensive study

I.V Zelepukin, A.V Yaremenko, I.N Ivanov, M.V Yuryev, V.R Cherkasov, S.M. Deyev, P.I. Nikitin, M.P. Nikitin

Acs Nano

DOI: 10.1021/acsnano.1c00687


8. Comparative evaluation of engineered polypeptide scaffolds in HER2-targeting magnetic nanocarrier delivery

V.O Shipunova, O.A Kolesnikova, P.A Kotelnikova, V.D Soloviev, A.A Popov, G. M. Proshkina, M. P. Nikitin, S.M. Deyev

ACS omega

DOI: 10.1021/acsomega.1c01811


9. Nonviral locally injected magnetic vectors for in vivo gene delivery: A review of studies on magnetofection

AA Sizikov, MV Kharlamova, MP Nikitin, PI Nikitin, EL Kolychev




10. In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors

A.B Mirkasymov, I.V Zelepukin, P.I Nikitin, M.P Nikitin, S.M Deyev

Journal of Controlled Release

DOI: 10.1016/j.jconrel.2020.12.004


11. PLGA Nanoparticles decorated with anti-HER2 affibody for targeted delivery and photoinduced cell death

V.O Shipunova, A.S Sogomonyan, I.V Zelepukin, M.P Nikitin, S.M Deyev


DOI: 10.3390/molecules26133955


12. Nanobiosensing based on optically selected antibodies and superparamagnetic labels for rapid and highly sensitive quantification of polyvalent hepatitis B surface antigen

V.A Bragina, A.V Orlov, S.L Znoyko, A.V Pushkarev, D.O Novichikhin, N. V Guteneva, M.P Nikitin, B.G Gorshkov,

P.I Nikitin

Analytical Methods

DOI:  10.1039/D1AY00354B





1. Fast processes of nanoparticle blood clearance: Comprehensive study

I.V. Zelepukin, A.V. Yaremenko, M.V. Yuryev, A.B. Mirkasymov, I.L. Sokolov, S.M .Deyev, P.I Nikitin, M.P. Nikitin

Journal of Controlled Release

DOI: 10.1016/j.jconrel.2020.07.014


2. Nanomagnetic lateral flow assay for high-precision quantification of diagnostically relevant concentrations of serum TSH

S.L. Znoyko, A.V. Orlov, V.A. Bragina, M.P. Nikitin, P.I. Nikitin.


DOI: 10.1016/j.talanta.2020.120961


3. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes

M.P. Nikitin, I.V. Zelepukin, V.O. Shipunova, I.L. Sokolov, S.M. Deyev, P.I. Nikitin

Nature Biomedical Engineering

DOI: 10.1038/s41551-020-0581-2


4. Dynamic light scattering biosensing based on analyte-induced inhibition of nanoparticle aggregation

A.D. Levin, A.Ringaci, M.K. Alenichev, E.B. Drozhzhennikova, , K.G. Shevchenko, V.R. Cherkasov, M.P. Nikitin , P.I. Nikitin

Analytical and bioanalytical chemistry

DOI: 10.1007/s00216-020-02605-9


5. Hematite nanoparticles from unexpected reaction of ferrihydrite with concentrated acids for biomedical applications

A.V. Lunin, A.A. Lizunova,  E.N. Mochalova,  M.N. Yakovtseva, V.R. Cherkasov


DOI: 10.3390/molecules25081984


6. Nanoparticle Beacons: Supersensitive Smart Materials with On/Off-Switchable Affinity to Biomedical Targets

V.R. Cherkasov, E.N. Mochalova, A.V. Babenyshev, A.V. Vasilyeva, P.I. Nikitin, M.P. Nikitin

ACS Nano 

DOI: 10.1021/acsnano.9b07569


7. Spindle-like MRI-active europium-doped iron oxide nanoparticles with shape-induced cytotoxicity from simple and facile ferrihydrite crystallization procedure

A.V. Lunin, I.L. Sokolov, I.V. Zelepukin, I.V. Zubarev, M.N. Yakovtseva, E. N. Mochalova, J.M. Rozenberg, M.P. Nikitin, E.L. Kolychev


DOI: 10.1039/C9RA10683A


8. Antibody-directed metal-organic framework nanoparticles for targeted drug delivery

V.R. Cherkasov, E.N. Mochalova, A.V. Babenyshev, J.M. Rozenberg, I.L. Sokolov, M.P. Nikitin

Acta Biomaterialia

DOI: 10.1016/j.actbio.2019.12.012


9. Precise quantitative analysis of cell targeting by particle-based agents using imaging flow cytometry and convolutional neural network

E.N. Mochalova, I.A. Kotov, J.M. Rozenberg, M.P. Nikitin

Cytom. Part A

DOI: 10.1002/cyto.a.23939


10. Development of magnetic particle-based theranostic agents with high specificity to cellular targets

E.N. Mochalova, M.N. Yakovtseva, S.P. Krechetov, V.R. Cherkasov, M.P. Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5


11. Smart Nanomaterials as Advanced Sensors and Targeted Drug Delivery Agents


Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5


12. Development of the enzyme-responsive nanoparticle-based system for targeted drug delivery

K.G. Shevchenko, A.Ringaci, A.V. Babenyshev, M. P Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-020-0248-5





1. Analytical Platform with Selectable Assay Parameters Based on Three Functions of Magnetic Nanoparticles: Demonstration of Highly Sensitive Rapid Quantitation of Staphylococcal Enterotoxin B in Food

V.A. Bragina, S.L. Znoyko, A.V. Orlov, A.V. Pushkarev, M.P. Nikitin, P.I. Nikitin

Anal. Chem.

DOI: 10.1021/acs.analchem.9b01519


2. Rapid lateral flow assays based on the quantification of magnetic nanoparticle labels for multiplexed immunodetection of small molecules: application to the determination of drugs of abuse

N.V. Guteneva, S.L. Znoyko, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

Mikrochim. Acta

DOI: 10.1007/s00604-019-3726-9


3. Nanoparticle-based drug delivery via RBC-hitchhiking for the inhibition of lung metastases growth

I.V. Zelepukin, A.V. Yaremenko, V.O. Shipunova, A.V. Babenyshev, I.V. Balalaeva,
P.I. Nikitin, S.M. Deyev, M.P. Nikitin


DOI: 10.1039/c8nr07730d


4. Interferometric detection of chloramphenicol via its immunochemical recognition at polymer-coated nano-corrugated surfaces

A.E. Ivanov, A.V. Pushkarev, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

Sens. Actuators B: Chem.  

DOI: 10.1016/j.snb.2018.11.043


5. Synthesis of highly-specific stable nanocrystalline goethite-like hydrous ferric oxide nanoparticles for biomedical applications by simple precipitation method

A.V. Lunin, E.L. Kolychev, E.N. Mochalova, V.R. Cherkasov, M.P. Nikitin 

J. Colloid Interface Sci. 

DOI: 10.1016/j.jcis.2019.01.065


6. Magnetometry based method for investigation of nanoparticle clearance from circulation in a liver perfusion model 

I.V. Zelepukin, A.V. Yaremenko, E.V. Petersen, S.M. Deyev, V.R. Cherkasov, P.I. Nikitin, M.P. Nikitin


DOI: 10.1088/1361-6528/aafa3a


7. Self-assembling nanoparticles biofunctionalized with magnetite-binding protein for the targeted delivery to HER2/neu overexpressing cancer cells

V.O. Shipunova, P.A Kotelnikova, U.F Aghayeva, O.A Stremovskiy, I.A Novikov, A.A Schulga, M.P Nikitin, S.M Deyev

J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2018.09.015


8. Nano-biosensors based on dynamic light scattering

A.D. Levin, M.P. Nikitin, M.K. Alenichev, E.B. Drozhzhennikova, V.G. Grigorenko, A.S. Ringaci, I.P. Andreeva

Proc. SPIE 

DOI: 10.1117/12.2526055


9. Development of the SPR based method for real-time monitoring of surface cell markers density 

K.G. Shevchenko, A.V. Lunin, A.V. Popova, E.L. Kolychev, B.G. Gorshkov, M.P. Nikitin

Cell Death Dis. 

DOI: 10.1038/s41420-018-0128-4


10. Drug delivery with functionalized magnetic metal-organic framework nanoparticles 

A.V. Babenyshev, K.G. Shevchenko, A.V. Yaremenko, V.R. Cherkasov, P.I. Nikitin, M.P. Nikitin

Cell Death Dis.

DOI: 10.1038/s41420-018-0128-4


11. Fabrication of Highly Specific Drug Delivery Nanoagents and Investigation of Their Interaction with Cells

E. N. Mochalova, I.L. Sokolov, I.L. Nikitina, A.V. Orlov, K.G. Shevchenko

Cell Death Dis. 

DOI: 10.1038/s41420-018-0128-4





1. Advanced smart nanomaterials with integrated logic-gating and biocomputing: dawn of theranostic nanorobots 

A.A. Tregubov, P.I. Nikitin, M.P. Nikitin

Chem. Rev. 

DOI: 10.1021/acs.chemrev.8b00198 


2. Versatile platform for nanoparticle surface bioengineering based on SiO2-binding peptide and proteinaceous barnase*barstar interface

V.O. Shipunova, I.V. Zelepukin, O.A. Stremovskiy, M.P. Nikitin, A. Care, A. Sunna, A.V. Zvyagin, S.M. Deyev

ACS Appl. Mater. Interfaces. 

DOI: 10.1021/acsami.8b01627


3. Ultrasensitive detection enabled by nonlinear magnetization of nanomagnetic labels

M.P. Nikitin, A.V. Orlov, I.L. Sokolov, A.A. Minakov, P.I. Nikitin, J. Ding, S.D. Bader, E.A. Rozhkova, V. Novosad


DOI: 10.1039/c8nr01511b


4. Development and label-free investigation of logic-gating biolayers for smart biosensing

A.V. Orlov, A.V. Pushkarev, E.N. Mochalova, P.I. Nikitin, M.P. Nikitin

Sens. Actuators B: Chem. 

DOI: 10.1016/j.snb.2017.11.025


5. Ultrasensitive quantitative detection of small molecules with rapid lateral-flow assay based on high-affinity bifunctional ligand and magnetic nanolabels

S.L. Znoyko, A.V. Orlov, A.V. Pushkarev, E.N. Mochalova, N.V. Guteneva, A.V. Lunin, M.P. Nikitin, P.I. Nikitin

Anal. Chim. Acta 

DOI: 10.1016/j.aca.2018.07.012


6. Multiplex biosensing with highly sensitive magnetic nanoparticle quantification method

M.P. Nikitin, A.V. Orlov, S.L. Znoyko, V.A. Bragina, B.G. Gorshkov, T.I. Ksenevich, V.R. Cherkasov, P.I. Nikitin

J. Magn. Magn. Mater.

DOI: 10.1016/j.jmmm.2017.10.078


7. Magnetic hybrid magnetite/metal organic framework nanoparticles: facile preparation, post-synthetic biofunctionalization and tracking in vivo with magnetic methods

A.A. Tregubov, I.L. Sokolov, A.V. Babenyshev, P.I. Nikitin, V.R. Cherkasov, M.P. Nikitin

J. Magn. Magn. Mater.  

DOI: 10.1016/j.jmmm.2017.10.070


8. Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

K.G. Shevchenko, V.R. Cherkasov, I.L. Nikitina, A.V. Babenyshev, M.P. Nikitin

Appl. Nanosci. 

DOI: 10.1007/s13204-018-0659-2


9. Smart ligand-sensitive monolayers based on modified liposomes for biomedical applications

A.V. Lunin, V.R. Cherkasov, M.P. Nikitin 

J. Bioenerg. Biomembr.  


10. Paramagnetic colloidal ferrihydrite nanoparticles for MRI contrasting

I.L. Sokolov, V.R. Cherkasov, A.V. Vasilyeva, V.A. Bragina, M.P. Nikitin

Colloids Surf. A Physicochem. Eng. Asp.  

DOI: 10.1016/j.colsurfa.2017.11.062


11. Synthesis of Magnetic Nanoparticles Stabilized by Magnetite-Binding Protein for Targeted Delivery to Cancer Cells

P.A. Kotelnikova, V.O. Shipunova, U.F. Aghayeva, O.A. Stremovskiy, M.P. Nikitin, I.A. Novikov, A.A. Schulga, S.M. Deyev, R.V. Petrov

Dokl. Biochem. Biophys. 

DOI: 10.1134/S1607672918040051


12. Data on characterization of magnetic nanoparticles stabilized with fusion protein of Barstar and C-term part of Mms6

V.O. Shipunova, P.A. Kotelnikova, U.F. Aghayeva, O.A. Stremovskiy, A.A. Schulga, M.P. Nikitin, S.M. Deyev 

Data in Brief 

DOI: 10.1016/j.dib.2018.10.173


13. Data on characterization and validation of assays for ultrasensitive quantitative detection of small molecules: Determination of free thyroxine with magnetic and interferometric methods

A.V. Orlov, S.L. Znoyko, A.V. Pushkarev, E.N. Mochalova, N.V. Guteneva, A.V. Lunin, M.P. Nikitin, P.I.  Nikitin

Data in Brief 

DOI: 10.1016/j.dib.2018.10.145


14. Volumetric registration of magnetic nanoparticles for optimization of quantitative immunochromatographic assays for detection of small molecules

N.V. Guteneva, S.L. Znoyko, A.V. Orlov, M.P. Nikitin, P.I. Nikitin

EPJ Web of Conferences 

DOI: 10.1051/epjconf/201818510006


15. Synthesis of Luminescent Magnetic Nanoparticles with Controllable Surface Properties 

I.V. Zelepukin,  V.O. Shipunova,  A.B. Mirkasymov,  P.I. Nikitin,  M.P. Nikitin,  S.M. Deyev

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435620


16. Intelligent Nanoparticle-Based Agents for Biomedical Applications: Rapid Design Using a Lateral Flow Assay

E.N. Mochalova, A.V. Pushkarev, P.I. Nikitin, M.P. Nikitin

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435254


17. Targeting of tumor tissues with magnetic nanoparticles 

M. Gonçalves,  R. Schwartz-Albiez,  P.I. Nikitin,  M.P. Nikitin,  F. Momburg

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435481


18. Smart Biolayers on Solid Phase: Rational Design and Investigation by Spectral-Phase Interferometry 

A.V. Pushkarev, E.N. Mochalova, S.L. Znoyko, M.P. Nikitin, A.V. Orlov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435399


19. Multifunctional Nanoagents for Logic-Gated Chemosensing, Diagnostics and Drug Delivery

M.P. Nikitin 

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435454


20. Modified Liposomes as Optical Probes, Magnetic Labels, and Drug Carriers

A.V. Lunin, A.V. Vasilyeva, B.G. Gorshkov, I.L. Sokolov, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435580


21. Nanocomplexes For in situ Detection of Small Molecules With Switchable Optical Properties

A.V. Babenyshev, K.G. Shevchenko, A.A. Tregubov, I.L. Nikitina, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435586


22. Development of SPR Based Tool For Monitoring of Self-Assembly of Heterogenous Nanoparticle Complexes

K.G. Shevchenko, A.V. Babenyshev, A.A. Tregubov, I.L. Nikitina, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435745


23. Fluorescent Superparamagnetic and Paramagnetic Agents for Bioimaging, Sensing and Cell Targeting

I.L. Sokolov, A.V. Vasilyeva, A.V. Lunin, A.V. Yaremenko, V.R. Cherkasov

Proceedings - International Conference Laser Optics 2018

DOI: 10.1109/LO.2018.8435453


24. Multiplex Express In Vitro Diagnostics based on Magnetic Nanoparticles

V.A. Bragina, B.G. Gorshkov, N.V. Guteneva, M.P. Nikitin, P.I. Nikitin, A.V. Orlov, S.L. Znoyko

TechConnect Briefs 




1. Rapid dry-reagent immunomagnetic biosensing platform based on volumetric detection of nanoparticles on 3D structures

A.V. Orlov, V.A. Bragina, M.P. Nikitin, P.I. Nikitin

Biosens. Bioelectron. 

DOI: 10.1016/j.bios.2015.12.049


2. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interaction

V.O. Shipunova, M.P. Nikitin*, P.I. Nikitin, S.M. Deyev (* –corresponding author)


DOI: 10.1039/c6nr03507h


3. Multiplex Biosensing Based on Highly Sensitive Magnetic Nanolabel Quantification: Rapid Detection of Botulinum Neurotoxins A, B, and E in Liquids

A.V. Orlov, S.L. Znoyko, V.R. Cherkasov, M.P. Nikitin, P.I. Nikitin

Anal. Chem. 

DOI: 10.1021/acs.analchem.6b02066


4. Synthesis of magnetic silica nanomarkers with controlled physicochemical properties

I.V. Zelepukin, M.P. Nikitin, V.R. Cherkasov, P.I. Nikitin, S.M. Deyev, P.V. Petrov

Dokl. Biochem. Biophys. 

DOI: 10.1134/S1607672916050100


5. Mössbauer and X-ray study of biodegradation of (Fe3O4)-Fe-57 magnetic nanoparticles in rat brain

R.R. Gabbasov, V.M. Cherepanov, M.A. Chuev, A.A. Lomov, I.N. Mischenko, M.P. Nikitin, M.A. Polikarpov, V.Y. Panchenko

Hyperfine Interactions 

DOI: 10.1007/s10751-016-1237-1


6. Stimuli-responsive Nano- and Microstructures Based on Gold Nanoparticles

K.G. Shevchenko, V.R. Cherkasov, I.L. Sokolov, M.P. Nikitin

Proc. of the 2016 International conference laser optics (LO) 

DOI: 10.1109/LO.2016.7550012


7. Near infrared luminescent– magnetic nanoparticles for bimodal imaging in vivo 

I. V. Zelepukin, M P. Nikitin, A. V. Nechaev, A. V. Zvyagin, P. I. Nikitin, S. M. Deyev

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7550011


8. Lectin-based nanoagents for specific cell labelling and optical visualization

V.O. Shipunova, M.P. Nikitin, P.I. Nikitin, S.M. Deyev

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7550004


9. Nanorobots for Biomedical Applications

M.P. Nikitin

Proc. of the 2016 International conference laser optics (LO)  

DOI: 10.1109/LO.2016.7549994




1. Direct immunosensing by spectral correlation interferometry: assay characteristics versus antibody immobilization chemistry

A.G. Burenin, A.E. Urusov, A.V. Betin, A.V. Orlov, M.P. Nikitin, T.I. Ksenevich, , B.G. Gorshkov, A.V. Zherdev, B.B. Dzantiev, P.I. Nikitin

Anal. Bioanal. Chem. 

DOI: 10.1007/s00216-015-8600-y


2. Mössbauer study of exogenous iron redistribution between the brain and the liver after administration of 57Fe3O4 ferrofluid in the ventricle of the rat brain

D. Polikarpov, R. Gabbasov, V. Cherepanov, N. Loginova, E. Loseva, M. Nikitin, A. Yurenia, V. Panchenko

J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2014.10.084


3. A new real-time method for investigation of affinity properties and binding kinetics of magnetic nanoparticles

A.V. Orlov, M.P. Nikitin, V.A. Bragina, S.L. Znoyko, M.N. Zaikina, T.I. Ksenevich, B.G. Gorshkov, P.I. Nikitin

 J. Magn. Magn. Mater. 

DOI: 10.1016/j.jmmm.2014.10.019


4. Комплексное изучение взаимодействий между лектинами и гликопротеинами для разработки эффективных тераностических наноагентов.

Шипунова В.О., Никитин М.П., ​​Зелепукин И.В., Никитин П.И., Деев С.М., Петров Р.В.

Докл. Биохим. Биофиз.  

DOI: 10.1134/S1607672915050117


5. Комплексы магнитных наночастиц и антител scFv для нацеливания и визуализации раковых клеток.

Шипунова В.О., Никитин М.П., ​​Миронова К.Е., Деев С.М., Никитин П.И.

15-я Международная конференция IEEE по нанотехнологиям (IEEE NANO) 

DOI: 10.1109/НАНО.2015.7388956


6. Комбинированная фотодинамическая термохимиотерапия глиальных опухолей под контролем МРТ и электронного датчика.

Н.А. Брусенцов, В.А. Полянский, А.В. Жуков, М.В. Гуляев, М.П. Никитин, П.И. Никитин, Т.Н. Брусенцова, В.Д. Кузнецов, О.А. Бочарова, А.Ю. Барышников

Твердотельные явления 

DOI: 10.4028/





1. Биокомпьютинг на основе разборки частиц

Никитин М.П., ​​Шипунова В.О., Деев С.М., Никитин П.И.


DOI: 10.1038/nnano.2014.156